Abstract Carbapenem-resistance in Klebsiella pneumoniae (KP) sequence type ST258 is mediated by carbapenemases (e.g.KPC-2) and loss or modification of the major non-selective porins OmpK35 and OmpK36.However, the mechanism underpinning OmpK36-mediated 8n joico lumishine resistance and consequences of these changes on pathogenicity remain unknown.By
Evaluating the Potency of Selected Antibiotic Medications Dispensed in Community Pharmacies in Gwale, Kano, Nigeria
The worsening of antibiotic resistance is a multifactorial process.One aspect of this is the counterfeiting of antibiotic medications.This is supposed to be particularly high in developing countries, including Nigeria.Therefore, the potency of some antibiotic drugs dispensed in community pharmacies in Gwale, Kano, Nigeria, was investigated in this
Progestins Upregulate FKBP51 Expression in Human Endometrial Stromal Cells to Induce Functional Progesterone and Glucocorticoid Withdrawal: Implications for Contraceptive- Associated Abnormal Uterine Bleeding.
Use of long-acting progestin only contraceptives (LAPCs) offers a discrete and highly effective family planning method.Abnormal uterine bleeding (AUB) is the major side effect of, and cause for, discontinuation of LAPCs.The endometria of LAPC-treated women display abnormally enlarged, fragile blood vessels, decreased endometrial blood flow and oxid
Comamonas testosteroni: Is It Still a Rare Human Pathogen
Comamonas testosteroni (formally Pseudomonas testosteroni) is common environmental bacterium that is not part of the human microbiome.Since its identification as a human pathogen in 1987, numerous reports have drizzled in, ceramic baffle board implicating this organism for various infections.Although these organisms are of low virulence, some of th